- Formulated for both anti-inflammatory, antifibrinolytic and immune-modulating activity as well as digestive benefit
- Diverse proteolytic activity with a broad range physiological functions and clinical uses extending well beyond protein digestion
- Unique, clinically effective, concentrated enzyme formulation containing pancreatic enzymes, papain, Peptizyme SP and bromelain
- Enteric coated tablets help protect the enzyme from the acidic environment of the stomach, allowing the high enzyme activity level to reach the small intestine
Synerase is a unique proteolytic enzyme combination with diverse clinical benefits, showing efficacy both for systemic inflammation as well as digestive function. This multienzyme formulation contains digestive enzymes with physiological influences extending well beyond protein digestion. This is in part due to the increase in food allergies as a result of incomplete protein digestion, which may be responsible for more systemic effects.Beyond protein digestion, bromelain has been shown to reduce blood viscosity, prevent aggregation of blood platelets, reduce levels of prostaglandin E2 and thromboxane A2, and in an open study it improved symptoms of mild, acute knee pain.Bromelain also has demonstrated immunomodulatory effects in a variety of models, preventing neutrophil migration in response to IL-8 during inflammation, and inhibiting pro-inflammatory chemokine and cytokine secretion.
Another component of Synerase, Peptizyme SP, has been evaluated in a number of clinical trials, demonstrating anti-inflammatory, anti-edemic and fibrinolytic properties, resulting in a significant reduction in symptoms for both acute and chronic ear, nose or throat disorders.8 It has also shown antimicrobial properties, modulating proteins involved in bacterial colonization, persistence and invasion.9